Keywords: پیازولو [1،5-a] پیریمیدین; Pyrazolo[1,5-a]pyrimidine; (Chlorocarbonyl)phenyl ketene; Density functional theory; 5-Amino pyrazolones
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Synthesis and antitumor activity of some new pyrazolo[1,5-a]pyrimidines
Keywords: پیازولو [1،5-a] پیریمیدین; 5-Amino-1H-pyrazole; Pyrazolo[1,5-a]pyrimidine; Schiff bases; MTT assay; Anticancer activity; Structure activity relationship;
Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors
Keywords: پیازولو [1،5-a] پیریمیدین; Malaria; P. falciparum; Pyrazolo[1,5-a]pyrimidine; Dihydroorotate dehydrogenase (DHODH); Molecular docking;
Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines
Keywords: پیازولو [1،5-a] پیریمیدین; Cyclin-dependent kinase 2; ATP-competitive type I inhibitors; Pyrazolo[1,5-a]pyrimidine; Quantum mechanical scoring; Protein-ligand binding; Molecular dynamics; Water thermodynamics; X-ray crystal structure;
An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold
Keywords: پیازولو [1،5-a] پیریمیدین; Pyrazolo[1,5-a]pyrimidine; Anti-cancer agents; Anti-infectious agents; CNS agents; Anti-inflammatory agents; Radiopharmaceuticals;
Design and synthesis of novel pyrazolo[1,5-a]pyrimidine derivatives bearing nitrogen mustard moiety and evaluation of their antitumor activity in vitro and in vivo
Keywords: پیازولو [1،5-a] پیریمیدین; Pyrazolo[1,5-a]pyrimidine; Nitrogen mustard derivatives; Anti-tumor; Cell cycle; Apoptosis; Xenograft mice model; MTT; (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; A549; human alveolar adenocarcinoma cell line; SH-SY5Y; human neuroblasto
Medicinal attributes of pyrazolo[1,5-a]pyrimidine based scaffold derivatives targeting kinases as anticancer agents
Keywords: پیازولو [1،5-a] پیریمیدین; Protein kinase; Bioisostere; Pyrazolo[1,5-a]pyrimidine; Anticancer;
Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO)
Keywords: پیازولو [1،5-a] پیریمیدین; Translocator protein; Pyrazolo[1,5-a]pyrimidine; DPA-714; Steroid; Positron emission tomography
A facile method for the synthesis of steroidal and nonsteroidal 5-methyl pyrazolo[1,5-a]pyrimidines
Keywords: پیازولو [1،5-a] پیریمیدین; Pyrazolo[1,5-a]pyrimidine; Steroid; Potassium tert-butoxide; Heterocycle; Amino-1H-pyrazole;
Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: Design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives
Keywords: پیازولو [1،5-a] پیریمیدین; BSZRGJKRHYXHIP-UHFFFAOYSA-N; JLTOSZWUKFGEJV-UHFFFAOYSA-N; WVZNAGYRPXFMRY-UHFFFAOYSA-N; ULRBWXYDRJNLNG-UHFFFAOYSA-N; YXLLVZNNNCCREE-UHFFFAOYSA-N; FYEKUVZLJJCIGP-UHFFFAOYSA-N; IYCQWQGKUDDQGF-UHFFFAOYSA-N; RZMXRCFAAJREMJ-UHFFFAOYSA-N; GYBQBADMBRADDS-UHFFFAOY
Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives
Keywords: پیازولو [1،5-a] پیریمیدین; 2-Acetyl tetralin; Enaminone; Pyranone; Pyrazolo[1,5-a]pyrimidine; 1,2,3-Triazolo[1,5-a]pyrimidine; Pyrido[2,3-d]pyrimidine; Mitochondrial membrane potential; Apoptosis
A facile one-pot synthesis of 7-substituted pyrazolo[1,5-a]pyrimidines by base induced three-component reaction
Keywords: پیازولو [1،5-a] پیریمیدین; Pyrazolo[1,5-a]pyrimidine; Steroid; Potassium tert-butoxide; Heterocycle; Amino-1H-pyrazole;
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach
Keywords: پیازولو [1،5-a] پیریمیدین; Pan–Pim kinase; pyrazolo[1,5-a]pyrimidine
A practical, multigram synthesis of the 2-(2-(4-alkoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide (DPA) class of high affinity translocator protein (TSPO) ligands
Keywords: پیازولو [1،5-a] پیریمیدین; Translocator protein; Pyrazolo[1,5-a]pyrimidine; DPA-714;
Regioselective synthesis of fused pyrazolo[1,5-a]pyrimidines by reaction of 5-amino-1H-pyrazoles and β-dicarbonyl compounds containing five-membered rings
Keywords: پیازولو [1،5-a] پیریمیدین; 5-Amino-1H-pyrazoles; 2-Aacetylcyclopentanone; 2-Ethoxycarbonylcyclopentanone; 2-Acetylbutyrolactone; Pyrazolo[1,5-a]pyrimidine;
Mg–Al hydrotalcites as efficient catalysts for aza-Michael addition reaction: A green protocol
Keywords: پیازولو [1،5-a] پیریمیدین; Mg–Al-hydrotalcite; Aza-Michael addition; Green protocol; Acidic/basic sites; Pyrazolo[1,5-a]pyrimidine; Microwave irradiations
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1
Keywords: پیازولو [1،5-a] پیریمیدین; Kinase; CHK1; Pyrazolo[1,5-a]pyrimidine; Template;
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 2
Keywords: پیازولو [1،5-a] پیریمیدین; Kinase; CHK1; Pyrazolo[1,5-a]pyrimidine; CDK; Cell cycle; Inhibitors;
Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists
Keywords: پیازولو [1،5-a] پیریمیدین; Obesity; NPY Y1R; Pyrazolo[1,5-a]pyrimidine
Single step synthesis of new fused pyrimidine derivatives and their evaluation as potent Aurora-A kinase inhibitors
Keywords: پیازولو [1،5-a] پیریمیدین; Aurora-A; Kinase inhibitors; Colon tumor; Pyrazolo[1,5-a]pyrimidine; Triazolo[1,5-a]pyrimidine; Pyrimido[1,2-a]benzimidazole; Structure–activity relationship (SAR); Molecular modeling
Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhib
Keywords: پیازولو [1،5-a] پیریمیدین; Dipeptidyl peptidase IV; DPP-IV inhibitor; Pyrazolo[1,5-a]pyrimidine; Anagliptin; Glucagon-like peptide-1; Type 2 diabetes mellitus;
Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO)
Keywords: پیازولو [1،5-a] پیریمیدین; Peripheral-type benzodiazepine receptor; Translocator protein; TSPO; Steroidogenesis; Pyrazolo[1,5-a]pyrimidine; Neurodegeneration; Neuroprotection; Microglia
Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moiety
Keywords: پیازولو [1،5-a] پیریمیدین; Benzothiazole; Thiazole; Thiophene; Pyrazole; Pyrazolo[1,5-a]pyrimidine; Antimicrobial activity
Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses
Keywords: پیازولو [1،5-a] پیریمیدین; Antiviral; Herpes simplex virus; Pyrazolo[1,5-c]pyrimidine; Pyrazolo[1,5-a]pyrimidine; Pyrazolo[1,5-a][1,3,5]triazine
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors
Keywords: پیازولو [1،5-a] پیریمیدین; Raf; Kinase; Inhibitor; Pyrazolo[1,5-a]pyrimidine
Highly regioselective synthesis of trifluoromethyl derivatives of pyrazolo[1,5-a]pyrimidines bearing fused cycloalkane rings using (2-ethoxycycloalkenyl)-2,2,2-trifluoroethanones
Keywords: پیازولو [1،5-a] پیریمیدین; Fluorine; Pyrazolo[1,5-a]pyrimidine; Regioselectivity; X-ray structure; 1H, 13C and 19F NMR
Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents
Keywords: پیازولو [1،5-a] پیریمیدین; Pyrazolo[1,5-a]pyrimidine; Checkpoint deficiency; p21 Deficient cells; Microtubulin binding; Anti-proliferative activity
Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety
Keywords: پیازولو [1،5-a] پیریمیدین; Antipyrine; Pyrazole; Pyrazolo[1,5-a]pyrimidine; Pyrazolo[3,4-d]triazine; Pyridine; Antimicrobial activity
Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety
Keywords: پیازولو [1،5-a] پیریمیدین; Analgesic; Anti-inflammatory; Phenylsulfonylpyrazole; Pyrazolo[1,5-a]pyrimidine; Triazolo[1,5-a]pyrimidine; Pyrimido[1,2-a]benzimidazole; Structure–activity relationship (SAR)
Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activity
Keywords: پیازولو [1،5-a] پیریمیدین; Phenylcarbamoylpyrazole; 1,2,4-Triazolo[4,3-a]pyrimidine; Pyrazolo[1,5-a]pyrimidine; Imidazo[2,1-b]benzothiazole; Enaminones; Antibacterial; Antifungal; Anticandidal; Structure–activity relationship (SAR); 2-Aminothiazole
Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2
Keywords: پیازولو [1،5-a] پیریمیدین; CDK2; Kinase; Inhibitors; Pyrazolo[1,5-a]pyrimidine
Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
Keywords: پیازولو [1،5-a] پیریمیدین; CDK2; Kinase inhibitors; Pyrazolo[1,5-a]pyrimidine
Synthesis of trifluoromethyl-promoted functional pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones
Keywords: پیازولو [1،5-a] پیریمیدین; Fluorine; Pyrazole; Pyrazolo[1,5-a]pyrimidine; Pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-one; Inhibitor
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2
Keywords: پیازولو [1،5-a] پیریمیدین; Pyrazolo[1,5-a]pyrimidine; CDK2; Cyclin-dependent kinase;